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KMID : 1138520050080010041
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Journal of Pharmacopuncture
2005 Volume.8 No. 1 p.41 ~ p.44
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Report on the changes of LD_{50} of Bee venom Herbal Acupuncture
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Kwon Ki-Rok
Jang Seong-Bong
Choi Young-Chon
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Abstract
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Objectives : This experiment was conducted to reevaluate LD_{50} of Korean bee venom acupuncture as many changes have occurred over the years.
Methods : ICR mice were used as the experiment animals and bee venom acupuncture was manufactured under the protocols of Korean Institute of herbal Acupuncture. Based on the previous reports, experiment was divided into pre and main sections.
Results : 1. Presumed LD_{50} value is at 5.25mg/kg 2. Deaths of experiment animals occurred within 48 hours. 3. Reduced toxicity of the bee venom acupuncture is likely to be the results of more refined manufacturing process and production.
Conclusion : Comparing with the values of the previous results, toxicity of the bee venom acupuncture showed significant changes and more accurate findings on LD_{50} value must be accomplished to lead further studies on the bee venom acupuncture.
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KEYWORD
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Bee Venom Herbal Acupuncture, $LD_{50}$, manufacturing process, toxin, venom
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